Ontology highlight
ABSTRACT:
SUBMITTER: Elsner DJ
PROVIDER: S-EPMC6768651 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Elsner Daniel J DJ Siess Katharina M KM Gossenreiter Thomas T Hartl Markus M Leonard Thomas A TA
The Journal of biological chemistry 20190812 39
Protein kinase D (PKD) is an essential Ser/Thr kinase in animals and controls a variety of diverse cellular functions, including vesicle trafficking and mitogenesis. PKD is activated by recruitment to membranes containing the lipid second messenger diacylglycerol (DAG) and subsequent phosphorylation of its activation loop. Here, we report the crystal structure of the PKD N terminus at 2.2 Å resolution containing a previously unannotated ubiquitin-like domain (ULD), which serves as a dimerization ...[more]