Ontology highlight
ABSTRACT:
SUBMITTER: Han D
PROVIDER: S-EPMC6768664 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Han Dandan D Schomacher Lars L Schüle Katrin M KM Mallick Medhavi M Musheev Michael U MU Karaulanov Emil E Krebs Laura L von Seggern Annika A Niehrs Christof C
eLife 20190930
Base excision repair (BER) functions not only in the maintenance of genomic integrity but also in active DNA demethylation and epigenetic gene regulation. This dual role raises the question if phenotypic abnormalities resulting from deficiency of BER factors are due to DNA damage or impaired DNA demethylation. Here we investigate the bifunctional DNA glycosylases/lyases NEIL1 and NEIL2, which act in repair of oxidative lesions and in epigenetic demethylation. <i>Neil</i>-deficiency in <i>Xenopus ...[more]