Clinical and pathological stage discordance among 433,514 breast cancer patients.
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ABSTRACT: Background
We aim to determine clinical and pathological stage discordance rates and to evaluate factors associated with discordance.Methods
Adults with clinical stages I-III breast cancer were identified from the National Cancer Data Base. Concordance was defined as cTN = pTN (discordance: cTN≠pTN). Multivariate logistic regression was used to identify factors associated with discordance.Results
Comparing clinical and pathological stage, 23.1% were downstaged and 8.7% were upstaged. After adjustment, factors associated with downstaging (vs concordance) included grade 3 (OR 10.56, vs grade 1) and HER2-negative (OR 3.79). Factors associated with upstaging (vs concordance) were grade 3 (OR 10.56, vs grade 1), HER2-negative (OR 1.25), and lobular histology (OR 2.47, vs ductal). ER-negative status was associated with stage concordance (vs downstaged or upstaged, OR 0.52 and 0.87).Conclusions
Among breast cancer patients, nearly one-third exhibit clinical-pathological stage discordance. This high likelihood of discordance is important to consider for counseling and treatment planning.
SUBMITTER: Plichta JK
PROVIDER: S-EPMC6768746 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Clinical and pathological stage discordance among 433,514 breast cancer patients.
Plichta Jennifer K JK Thomas Samantha M SM Sergesketter Amanda R AR Greenup Rachel A RA Fayanju Oluwadamilola M OM Rosenberger Laura H LH Tamirisa Nina N Hyslop Terry T Hwang E Shelley ES
American journal of surgery 20190718 4
<h4>Background</h4>We aim to determine clinical and pathological stage discordance rates and to evaluate factors associated with discordance.<h4>Methods</h4>Adults with clinical stages I-III breast cancer were identified from the National Cancer Data Base. Concordance was defined as cTN = pTN (discordance: cTN≠pTN). Multivariate logistic regression was used to identify factors associated with discordance.<h4>Results</h4>Comparing clinical and pathological stage, 23.1% were downstaged and 8.7% we ...[more]
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