Clinical and pathological stage discordance among 433,514 breast cancer patients.

ABSTRACT:

Background

We aim to determine clinical and pathological stage discordance rates and to evaluate factors associated with discordance.

Methods

Adults with clinical stages I-III breast cancer were identified from the National Cancer Data Base. Concordance was defined as cTN = pTN (discordance: cTN≠pTN). Multivariate logistic regression was used to identify factors associated with discordance.

Results

Comparing clinical and pathological stage, 23.1% were downstaged and 8.7% were upstaged. After adjustment, factors associated with downstaging (vs concordance) included grade 3 (OR 10.56, vs grade 1) and HER2-negative (OR 3.79). Factors associated with upstaging (vs concordance) were grade 3 (OR 10.56, vs grade 1), HER2-negative (OR 1.25), and lobular histology (OR 2.47, vs

SUBMITTER: Plichta JK 

PROVIDER: S-EPMC6768746 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature