Ontology highlight
ABSTRACT:
SUBMITTER: Schreck KC
PROVIDER: S-EPMC6769482 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Schreck Karisa C KC Grossman Stuart A SA Pratilas Christine A CA
Cancers 20190828 9
BRAF mutations have been identified as targetable, oncogenic mutations in many cancers. Given the paucity of treatments for primary brain tumors and the poor prognosis associated with high-grade gliomas, BRAF mutations in glioma are of considerable interest. In this review, we present the spectrum of BRAF mutations and fusion alterations present in each class of primary brain tumor based on publicly available databases and publications. We also summarize clinical experience with RAF and MEK inhi ...[more]