Ontology highlight
ABSTRACT:
SUBMITTER: Schmidtova S
PROVIDER: S-EPMC6769487 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Schmidtova Silvia S Kalavska Katarina K Gercakova Katarina K Cierna Zuzana Z Miklikova Svetlana S Smolkova Bozena B Buocikova Verona V Miskovska Viera V Durinikova Erika E Burikova Monika M Chovanec Michal M Matuskova Miroslava M Mego Michal M Kucerova Lucia L
Cancers 20190822 9
Cisplatin resistance in testicular germ cell tumors (TGCTs) is a clinical challenge. We investigated the underlying mechanisms associated with cancer stem cell (CSC) markers and modalities circumventing the chemoresistance. Chemoresistant models (designated as CisR) of human embryonal carcinoma cell lines NTERA-2 and NCCIT were derived and characterized using flow cytometry, gene expression, functional and protein arrays. Tumorigenicity was determined on immunodeficient mouse model. Disulfiram w ...[more]