Protein S100-A7 Derived from Digested Dentin Is a Critical Molecule for Dentin Pulp Regeneration.
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ABSTRACT:
SUBMITTER: Komichi S
PROVIDER: S-EPMC6769619 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Protein S100-A7 Derived from Digested Dentin Is a Critical Molecule for Dentin Pulp Regeneration.
Komichi Shungo S Takahashi Yusuke Y Okamoto Motoki M Ali Manahil M Watanabe Masakatsu M Huang Hailing H Nakai Takeo T Cooper Paul P Hayashi Mikako M
Cells 20190829 9
Dentin consists of inorganic hard tissue and organic dentin matrix components (DMCs). Various kinds of bioactive molecules are included in DMCs and some of them can be released after digestion by endogenous matrix metalloproteinases (MMPs) in the caries region. Digested DMCs induced by MMP20 have been reported to promote pulpal wound healing processes, but the released critical molecules responsible for this phenomenon are unclear. Here, we identified protein S100-A7 as a critical molecule for p ...[more]
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