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Genome-Wide SNPs and InDels Characteristics of Three Chinese Cattle Breeds.


ABSTRACT: We report genome characterization of three native Chinese cattle breeds discovering ~34.3 M SNPs and ~3.8 M InDels using whole genome resequencing. On average, 10.4 M SNPs were shared amongst the three cattle breeds, whereas, 3.0 M, 4.9 M and 5.8 M were specific to LQ, WN and WS breeds, respectively. Gene ontology (GO)analysis revealed four immune response-related GO terms were over represented in all samples, while two immune signaling pathways were significantly over-represented in WS cattle. Altogether, we found immune related genes (PGLYRP2, ROMO1, FYB2, CD46, TSC1) in the three cattle breeds. Our study provides insights into the genetic basis of Chinese indicine adaptation to the tropic and subtropical environment, and provides a valuable resource for further investigations of genetic characteristics of the three breeds.

SUBMITTER: Zhang F 

PROVIDER: S-EPMC6769757 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Genome-Wide SNPs and InDels Characteristics of Three Chinese Cattle Breeds.

Zhang Fengwei F   Qu Kaixing K   Chen Ningbo N   Hanif Quratulain Q   Jia Yutang Y   Huang Yongzhen Y   Dang Ruihua R   Zhang Jicai J   Lan Xianyong X   Chen Hong H   Huang Bizhi B   Lei Chuzhao C  

Animals : an open access journal from MDPI 20190822 9


We report genome characterization of three native Chinese cattle breeds discovering ~34.3 M SNPs and ~3.8 M InDels using whole genome resequencing. On average, 10.4 M SNPs were shared amongst the three cattle breeds, whereas, 3.0 M, 4.9 M and 5.8 M were specific to LQ, WN and WS breeds, respectively. Gene ontology (GO)analysis revealed four immune response-related GO terms were over represented in all samples, while two immune signaling pathways were significantly over-represented in WS cattle.  ...[more]

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