Ontology highlight
ABSTRACT:
SUBMITTER: Chaves G
PROVIDER: S-EPMC6769852 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Chaves Gepoliano G Stanley John J Pourmand Nader N
Cells 20190823 9
A higher incidence of diabetes was observed among family members of individuals affected by Huntington's Disease with no follow-up studies investigating the genetic nature of the observation. Using a genome-wide association study (GWAS), RNA sequencing (RNA-Seq) analysis and western blotting of <i>Rattus norvegicus</i> and human, we were able to identify that the gene family of sortilin receptors was affected in Huntington's Disease patients. We observed that less than 5% of SNPs were of statist ...[more]