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Extra Virgin Olive Oil: Lesson from Nutrigenomics.

ABSTRACT: Extra virgin olive oil (EVOO) consumption has a beneficial effect on human health, especially for prevention of cardiovascular disease and metabolic disorders. Here we underscore the peculiar importance of specific cultivars used for EVOO production since biodiversity among cultivars in terms of fatty acids and polyphenols content could differently impact on the metabolic homeostasis. In this respect, the nutrigenomic approach could be very useful to fully dissect the pathways modulated by different EVOO cultivars in terms of mRNA and microRNA transcriptome. The identification of genes and miRNAs modulated by specific EVOO cultivars could also help to discover novel nutritional biomarkers for prevention and/or prognosis of human disease. Thus, the nutrigenomic approach depicts a novel scenario to investigate if a specific EVOO cultivar could have a positive effect on human health by preventing the onset of cardiovascular disease and/or chronic inflammatory disorders also leading to cancer.

SUBMITTER: De Santis S

PROVIDER: S-EPMC6770023 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Extra Virgin Olive Oil: Lesson from Nutrigenomics.

De Santis Stefania S Cariello Marica M Piccinin Elena E Sabbà Carlo C Moschetta Antonio A

Nutrients 20190904 9

Extra virgin olive oil (EVOO) consumption has a beneficial effect on human health, especially for prevention of cardiovascular disease and metabolic disorders. Here we underscore the peculiar importance of specific cultivars used for EVOO production since biodiversity among cultivars in terms of fatty acids and polyphenols content could differently impact on the metabolic homeostasis. In this respect, the nutrigenomic approach could be very useful to fully dissect the pathways modulated by diffe ...[more]

PMID: 31487787

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Proteomics of extra virgin olive oil (EVOO)

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| S-EPMC9145083 | biostudies-literature

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