Conflicting Roles of 20-HETE in Hypertension and Stroke.
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ABSTRACT:
SUBMITTER: Shekhar S
PROVIDER: S-EPMC6770042 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Conflicting Roles of 20-HETE in Hypertension and Stroke.
Shekhar Shashank S Varghese Kevin K Li Man M Fan Letao L Booz George W GW Roman Richard J RJ Fan Fan F
International journal of molecular sciences 20190911 18
Hypertension is the most common modifiable risk factor for stroke, and understanding the underlying mechanisms of hypertension and hypertension-related stroke is crucial. 20-hydroxy-5, 8, 11, 14-eicosatetraenoic acid (20-HETE), which plays an important role in vasoconstriction, autoregulation, endothelial dysfunction, angiogenesis, inflammation, and blood-brain barrier integrity, has been linked to hypertension and stroke. 20-HETE can promote hypertension by potentiating the vascular response to ...[more]
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