Ontology highlight
ABSTRACT:
SUBMITTER: Munoz D
PROVIDER: S-EPMC6770071 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Muñoz Diego D Brucoli Martina M Zecchini Silvia S Sandoval-Hernandez Adrian A Arboleda Gonzalo G Lopez-Vallejo Fabian F Delgado Wilman W Giovarelli Matteo M Coazzoli Marco M Catalani Elisabetta E De Palma Clara C Perrotta Cristiana C Cuca Luis L Clementi Emilio E Cervia Davide D
Cancers 20190909 9
X-linked inhibitor of apoptosis protein (XIAP) is an emerging crucial therapeutic target in cancer. We report on the discovery and characterisation of small organic molecules from <i>Piper</i> genus plants exhibiting XIAP antagonism, namely erioquinol, a quinol substituted in the 4-position with an alkenyl group and the alkenylphenols eriopodols A-C. Another isolated compound was originally identified as gibbilimbol B. Erioquinol was the most potent inhibitor of human cancer cell viability when ...[more]