Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis.
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ABSTRACT:
SUBMITTER: Cosin-Roger J
PROVIDER: S-EPMC6770118 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis.
Cosin-Roger Jesus J Canet Francisco F Macias-Ceja Dulce C DC Gisbert-Ferrándiz Laura L Ortiz-Masiá Dolores D Esplugues Juan V JV Alós Rafael R Navarro Francisco F Barrachina María D MD Calatayud Sara S
Cells 20190913 9
We recently observed reduced autophagy in Crohn's disease patients and an anti-inflammatory effect of autophagy stimulation in murine colitis, but both anti- and pro-fibrotic effects are associated with autophagy stimulation in different tissues, and fibrosis is a frequent complication of Crohn's disease. Thus, we analyzed the effects of pharmacological modulation of autophagy in a murine model of intestinal fibrosis and detected that autophagy inhibition aggravates, while autophagy stimulation ...[more]
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