Ontology highlight
ABSTRACT:
SUBMITTER: Lund J
PROVIDER: S-EPMC6770141 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Lund Jenny J Ouwens D Margriet DM Wettergreen Marianne M Bakke Siril S SS Thoresen G Hege GH Aas Vigdis V
Cells 20190918 9
Previous studies have shown that chronic hyperglycemia impairs glucose and fatty acid oxidation in cultured human myotubes. To further study the hyperglycemia-induced suppression of oxidation, lactate oxidation, mitochondrial function and glycolytic rate were evaluated. Further, we examined the intracellular content of reactive oxygen species (ROS), production of lactate and conducted pathway-ANOVA analysis on microarray data. In addition, the roles of the pentose phosphate pathway (PPP) and the ...[more]