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Kinase Inhibitors and Ovarian Cancer.

ABSTRACT: Ovarian cancer is fifth in the rankings of cancer deaths among women, and accounts for more deaths than any other gynecological malignancy. Despite some improvement in overall-(OS) and progression-free survival (PFS) following surgery and first-line chemotherapy, there is a need for development of novel and more effective therapeutic strategies. In this mini review, we provide a summary of the current landscape of the clinical use of tyrosine kinase inhibitors (TKIs) and mechanistic target of rapamycin (mTOR) inhibitors in ovarian cancer. Emerging data from phase I and II trials reveals that a combinatorial treatment that includes TKIs and chemotherapy agents seems promising in terms of PFS despite some adverse effects recorded; whereas the use of mTOR inhibitors seems less effective. There is a need for further research into the inhibition of multiple signaling pathways in ovarian cancer and progression to phase III trials for drugs that seem most promising.

SUBMITTER: Katopodis P

PROVIDER: S-EPMC6770231 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Kinase Inhibitors and Ovarian Cancer.

Katopodis Periklis P Chudasama Dimple D Chudasama Dimple D Wander Gurleen G Sales Louise L Kumar Juhi J Pandhal Manreen M Anikin Vladimir V Chatterjee Jayanta J Hall Marcia M Karteris Emmanouil E

Cancers 20190912 9

Ovarian cancer is fifth in the rankings of cancer deaths among women, and accounts for more deaths than any other gynecological malignancy. Despite some improvement in overall-(OS) and progression-free survival (PFS) following surgery and first-line chemotherapy, there is a need for development of novel and more effective therapeutic strategies. In this mini review, we provide a summary of the current landscape of the clinical use of tyrosine kinase inhibitors (TKIs) and mechanistic target of ra ...[more]

PMID: 31547471

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