Ontology highlight
ABSTRACT:
SUBMITTER: Lees JG
PROVIDER: S-EPMC6770295 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Lees Jarmon G JG Kong Anne M AM Chen Yi C YC Sivakumaran Priyadharshini P Hernández Damián D Pébay Alice A Harvey Alexandra J AJ Gardner David K DK Lim Shiang Y SY
Stem cells international 20190919
Human induced pluripotent stem cells (iPSCs) can be differentiated <i>in vitro</i> into <i>bona fide</i> cardiomyocytes for disease modelling and personalized medicine. Mitochondrial morphology and metabolism change dramatically as iPSCs differentiate into mesodermal cardiac lineages. Inhibiting mitochondrial fission has been shown to promote cardiac differentiation of iPSCs. However, the effect of hydrazone M1, a small molecule that promotes mitochondrial fusion, on cardiac mesodermal commitmen ...[more]