Ontology highlight
ABSTRACT:
SUBMITTER: Barresi V
PROVIDER: S-EPMC6770353 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Barresi Valeria V Simbolo Michele M Mafficini Andrea A Piredda Maria Liliana ML Caffo Maria M Cardali Salvatore Massimiliano SM Germanò Antonino A Cingarlini Sara S Ghimenton Claudio C Scarpa Aldo A
Cancers 20190830 9
<h4>Background</h4>Glioblastomas (GBMs) are classified into isocitrate dehydrogenase (<i>IDH</i>) mutants and IDH wild-types (<i>IDH</i>-wt). This study aimed at identifying the mutational assets of <i>IDH</i>-wt GBMs in patients aged 18-54 years for which limited data are available.<h4>Methods</h4>Sixteen <i>IDH</i>-wt GBMs from adults < 55 years old were explored for mutations, copy number variations, tumour mutational load (TML), and mutational spectrum by a 409 genes TML panel.<h4>Results</h ...[more]