Single-Cell Transcriptomes Reveal Characteristic Features of Mouse Hepatocytes with Liver Cholestatic Injury.
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SUBMITTER: Chang N
PROVIDER: S-EPMC6770527 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
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Single-Cell Transcriptomes Reveal Characteristic Features of Mouse Hepatocytes with Liver Cholestatic Injury.
Chang Na N Tian Lei L Ji Xiaofang X Zhou Xuan X Hou Lei L Zhao Xinhao X Yang Yuanru Y Yang Lin L Li Liying L
Cells 20190911 9
Hepatocytes are the main parenchymal cells of the liver and play important roles in liver homeostasis and disease process. The heterogeneity of normal hepatocytes has been reported, but there is little knowledge about hepatocyte subtype and distinctive functions during liver cholestatic injury. Bile duct ligation (BDL)-induced mouse liver injury model was employed, and single-cell RNA sequencing was performed. Western blot and qPCR were used to study gene expression. Immunofluoresence was employ ...[more]
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