Matryoshka-Type Liposomes Offer the Improved Delivery of Temoporfin to Tumor Spheroids.
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ABSTRACT:
SUBMITTER: Yakavets I
PROVIDER: S-EPMC6770699 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
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Matryoshka-Type Liposomes Offer the Improved Delivery of Temoporfin to Tumor Spheroids.
Yakavets Ilya I Millard Marie M Lamy Laureline L Francois Aurelie A Scheglmann Dietrich D Wiehe Arno A Lassalle Henri-Pierre HP Zorin Vladimir V Bezdetnaya Lina L
Cancers 20190913 9
The balance between the amount of drug delivered to tumor tissue and the homogeneity of its distribution is a challenge in the efficient delivery of photosensitizers (PSs) in photodynamic therapy (PDT) of cancer. To date, many efforts have been made using various nanomaterials to efficiently deliver temoporfin (mTHPC), one of the most potent photosensitizers. The present study aimed to develop double-loaded matryoshka-type hybrid nanoparticles encapsulating mTHPC/cyclodextrin inclusion complexes ...[more]
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