Somatic Mutations of lats2 Cause Peripheral Nerve Sheath Tumors in Zebrafish.
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ABSTRACT:
SUBMITTER: Brandt ZJ
PROVIDER: S-EPMC6770745 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
Somatic Mutations of <i>lats2</i> Cause Peripheral Nerve Sheath Tumors in Zebrafish.
Brandt Zachary J ZJ North Paula N PN Link Brian A BA
Cells 20190825 9
The cellular signaling pathways underlying peripheral nerve sheath tumor (PNST) formation are poorly understood. Hippo signaling has been recently implicated in the biology of various cancers, and is thought to function downstream of mutations in the known PNST driver, <i>NF2</i>. Utilizing CRISPR-Cas9 gene editing, we targeted the canonical Hippo signaling kinase Lats2. We show that, while germline deletion leads to early lethality, targeted somatic mutations of zebrafish <i>lats2</i> leads to ...[more]
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