Ontology highlight
ABSTRACT:
SUBMITTER: Rudicell RS
PROVIDER: S-EPMC6771022 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Rudicell Rebecca S RS Garinot Marie M Kanekiyo Masaru M Kamp Heather D HD Swanson Kurt K Chou Te-Hui TH Dai Shujia S Bedel Olivier O Simard Daniel D Gillespie Rebecca A RA Yang Kanwen K Reardon Michael M Avila Luis Z LZ Besev Magnus M Dhal Pradeep K PK Dharanipragada Ram R Zheng Lingyi L Duan Xiaochu X Dinapoli Joshua J Vogel Thorsten U TU Kleanthous Harry H Mascola John R JR Graham Barney S BS Haensler Jean J Wei Chih-Jen CJ Nabel Gary J GJ
Vaccine 20190905 42
Seasonal influenza vaccines represent a positive intervention to limit the spread of the virus and protect public health. Yet continual influenza evolution and its ability to evade immunity pose a constant threat. For these reasons, vaccines with improved potency and breadth of protection remain an important need. We previously developed a next-generation influenza vaccine that displays the trimeric influenza hemagglutinin (HA) on a ferritin nanoparticle (NP) to optimize its presentation. Simila ...[more]