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All-cause mortality in patients with treatment-resistant depression: a cohort study in the US population.


ABSTRACT: Background:Treatment-resistant depression (TRD) may represent a substantial proportion of major depressive disorder (MDD); however, the risk of mortality in TRD is still incompletely assessed. Methods:Data were obtained from Optum Clinformatics™ Extended, a US claims database. Date of the first antidepressant (AD) dispensing was designated as the index date for study entry and 6 months prior to that was considered the baseline period. Patients with MDD aged ??18 years, index date between January 1, 2008 and September 30, 2015, no AD claims during baseline, and continuous enrollment in the database during baseline were included. Patients who started a third AD regimen after two regimens of appropriate duration were included in the TRD cohort. All-cause mortality was compared between patients with TRD and non-TRD MDD using a proportional hazards model and Kaplan-Meier estimate with TRD status being treated as a time-varying covariate. The model was adjusted for study year, age, gender, depression diagnosis, substance use disorder, psychiatric comorbidities, and Charlson comorbidity index. Results:Out of 355,942 patients with MDD, 34,176 (9.6%) met the criterion for TRD. TRD was associated with a significantly higher mortality compared with non-TRD MDD (adjusted HR: 1.29; 95% CI 1.22-1.38; p?

SUBMITTER: Li G 

PROVIDER: S-EPMC6771113 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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All-cause mortality in patients with treatment-resistant depression: a cohort study in the US population.

Li Gang G   Fife Daniel D   Wang Grace G   Sheehan John J JJ   Bodén Robert R   Brandt Lena L   Brenner Philip P   Reutfors Johan J   DiBernardo Allitia A  

Annals of general psychiatry 20190930


<h4>Background</h4>Treatment-resistant depression (TRD) may represent a substantial proportion of major depressive disorder (MDD); however, the risk of mortality in TRD is still incompletely assessed.<h4>Methods</h4>Data were obtained from Optum Clinformatics™ Extended, a US claims database. Date of the first antidepressant (AD) dispensing was designated as the index date for study entry and 6 months prior to that was considered the baseline period. Patients with MDD aged ≥ 18 years, index date  ...[more]

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