Ontology highlight
ABSTRACT:
SUBMITTER: Dickow J
PROVIDER: S-EPMC6771563 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Dickow Julia J Francois Sandra S Kaiserling Rouven-Luca RL Malyshkina Anna A Drexler Ingo I Westendorf Astrid Maria AM Lang Karl Sebastian KS Santiago Mario L ML Dittmer Ulf U Sutter Kathrin K
Frontiers in immunology 20190924
Clinical administration of Interferon α (IFNα) resulted in limited therapeutic success against some viral infections. Immune modulation of CD8<sup>+</sup> T cell responses during IFNα therapy is believed to play a pivotal role in promoting viral clearance. However, these clinical studies primarily focused on IFNα subtype 2. To date, the immunomodulatory roles of the remaining 10-13 IFNα subtypes remains poorly understood, thereby precluding assessments of their potential for more effective treat ...[more]