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T-cell-derived cytokines enhance the antigen-presenting capacity of human neutrophils.

ABSTRACT: Activated allergen-specific Th2 and Th1 cells release cytokines that transform neutrophils into functional APCs characterized by the expression of HLA-DR and CD58 as well as enhanced survival and antigen uptake, irrespectively of the presence of IL-10, which reduces allergen uptake by neutrophils.

SUBMITTER: Samadi N

PROVIDER: S-EPMC6771661 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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T-cell-derived cytokines enhance the antigen-presenting capacity of human neutrophils.

Samadi Nazanin N Polak Dominika D Kitzmüller Claudia C Steinberger Peter P Zlabinger Gerhard J GJ Jahn-Schmid Beatrice B Bohle Barbara B

European journal of immunology 20190806 9

Activated allergen-specific Th2 and Th1 cells release cytokines that transform neutrophils into functional APCs characterized by the expression of HLA-DR and CD58 as well as enhanced survival and antigen uptake, irrespectively of the presence of IL-10, which reduces allergen uptake by neutrophils. ...[more]

PMID: 31332790

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Human neutrophils require short exposure to cytokines and allergen to become functional antigen‐presenting cells

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