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Exendin-4 analogs in insulinoma theranostics.

ABSTRACT: Insulinomas, neuroendocrine tumors arising from pancreatic beta cells, often show overexpression of the glucagon-like peptide-1 receptor. Therefore, imaging with glucagon-like peptide analog exendin-4 can be used for diagnosis and preoperative localization. This review presents an overview of the development and clinical implementation of exendin-based tracers for nuclear imaging, and the potential use of exendin-4 based tracers for optical imaging and therapeutic applications such as peptide receptor radionuclide therapy or targeted photodynamic therapy.

SUBMITTER: Jansen TJP

PROVIDER: S-EPMC6771680 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Exendin-4 analogs in insulinoma theranostics.

Jansen Tom J P TJP van Lith Sanne A M SAM Boss Marti M Brom Maarten M Joosten Lieke L Béhé Martin M Buitinga Mijke M Gotthardt Martin M

Journal of labelled compounds & radiopharmaceuticals 20190801 10

Insulinomas, neuroendocrine tumors arising from pancreatic beta cells, often show overexpression of the glucagon-like peptide-1 receptor. Therefore, imaging with glucagon-like peptide analog exendin-4 can be used for diagnosis and preoperative localization. This review presents an overview of the development and clinical implementation of exendin-based tracers for nuclear imaging, and the potential use of exendin-4 based tracers for optical imaging and therapeutic applications such as peptide re ...[more]

PMID: 31070270

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Dataset Information

Exendin-4 analogs in insulinoma theranostics.

Publications

Exendin-4 analogs in insulinoma theranostics.

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