Dataset Information
TWIST2: A new candidate tumor suppressor in prostate cancer.
Ontology highlight
ABSTRACT: Background
Prostate cancer (PCa) is a leading cause of cancer morbidity and mortality in men worldwide; however, PCa incidence and mortality rates vary widely across geographic regions and ethnic groups. The current study was designed to elucidate the pivotal factors involved in PCa occurrence and development.Methods
We performed RNA sequencing on the prostate tumor and adjacent normal tissues from Chinese PCa patients. Genes identified via genome-wide expression profile analysis were validated by quantitative reverse-transcription polymerase chain reaction and immunohistochemistry. Hypermethylation of CpG islands was assessed by nested methylation-specific PCR. Whole genome microarray analysis was performed using an Affymetrix GeneChip.Results
We identified nine possible abnormally expressed genes (P?ConclusionsOur results suggest that TWIST2 could function as a tumor suppressor involved in the pathogenesis of PCa by influencing the expression of target genes and that hypermethylation of the TWIST2 promoter in prostate tumors may be an underlying mechanism for TWIST2 transcriptional silencing.
SUBMITTER: Zhao C
PROVIDER: S-EPMC6771699 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
TWIST2: A new candidate tumor suppressor in prostate cancer.
The Prostate 20190821 14
<h4>Background</h4>Prostate cancer (PCa) is a leading cause of cancer morbidity and mortality in men worldwide; however, PCa incidence and mortality rates vary widely across geographic regions and ethnic groups. The current study was designed to elucidate the pivotal factors involved in PCa occurrence and development.<h4>Methods</h4>We performed RNA sequencing on the prostate tumor and adjacent normal tissues from Chinese PCa patients. Genes identified via genome-wide expression profile analysis ...[more]
