Targeting the potassium ion channel genes SK and SH as a novel approach for control of insect pests: efficacy and biosafety.
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ABSTRACT:
SUBMITTER: Alshukri B
PROVIDER: S-EPMC6771844 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Targeting the potassium ion channel genes SK and SH as a novel approach for control of insect pests: efficacy and biosafety.
Alshukri Baida B Astarita Federica F Al-Esawy Mushtaq M El Halim Hesham Mohamed El Sayed Abd HMESA Pennacchio Francesco F Gatehouse Angharad Margaret Roscoe AMR Edwards Martin Gethin MG
Pest management science 20190729 9
<h4>Background</h4>Potassium ion channels play a critical role in the generation of electrical signals and thus provide potential targets for control of insect pests by RNA interference.<h4>Results</h4>Genes encoding the small conductance calcium-activated potassium channel (SK) and the voltage-gated potassium channel (SH) were knocked down in Tribolium castaneum by injection and oral delivery of dsRNA (dsTcSK and dsTcSH, respectively). Irrespective of the delivery mechanism a dose-dependent eff ...[more]
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