Fast-acting insulin aspart in people with type 2 diabetes: Earlier onset and greater initial exposure and glucose-lowering effect compared with insulin aspart.

ABSTRACT: AIMS:To investigate the pharmacokinetic/pharmacodynamic properties of fast-acting insulin aspart (faster aspart) versus insulin aspart (IAsp) in people with type 2 diabetes (T2D). MATERIALS AND METHODS:In a randomized, double-blind, crossover design, 61 people with T2D usually treated with insulin?±?oral antidiabetic drug(s) received single-dose faster aspart and IAsp (0.3 U/kg) on separate visits. Blood samples for pharmacokinetic assessment were collected frequently until 12?hours post-dose. Glucose-lowering effect was determined in a euglycaemic clamp lasting up to 12?hours post-dose (target 5.0 mmol/L). RESULTS:The serum IAsp pharmacokinetic profile and glucose-lowering effect profile were shifted to the left for faster aspart versus IAsp. Least squares mean (± SE) onset of appearance was 3.3?±?0.3 minutes for faster aspart, which was 1.2 minutes earlier than for IAsp (95% confidence interval [CI] -1.8;-0.5; P?=?.001). Onset of action for faster aspart was 8.9 minutes earlier (95% CI -12.1;-5.7; P?

SUBMITTER: Pieber TR 

PROVIDER: S-EPMC6771872 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature