Effects of common genetic variants associated with colorectal cancer risk on survival outcomes after diagnosis: A large population-based cohort study.
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ABSTRACT:
SUBMITTER: He Y
PROVIDER: S-EPMC6771941 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
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Effects of common genetic variants associated with colorectal cancer risk on survival outcomes after diagnosis: A large population-based cohort study.
He Yazhou Y Theodoratou Evropi E Li Xue X Din Farhat V N FVN Vaughan-Shaw Peter P Svinti Victoria V Farrington Susan M SM Campbell Harry H Dunlop Malcolm G MG Timofeeva Maria M
International journal of cancer 20190727 9
Genome-wide association studies have thus far identified 130 genetic variants linked to colorectal cancer (CRC) risk (r<sup>2</sup> < 0.2). Given their implication in disease causation, and thus plausible biologically effects on cancer-relevant biological pathways, we investigated whether these variants are associated with CRC prognosis and also whether they might provide predictive value for survival outcome. We conducted the analysis in a well-characterized population-based study of 5,675 pat ...[more]
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