Ruthenium and Iron-Catalysed Decarboxylative N-alkylation of Cyclic ?-Amino Acids with Alcohols: Sustainable Routes to Pyrrolidine and Piperidine Derivatives.

ABSTRACT: A modular and waste-free strategy for constructing N-substituted cyclic amines via decarboxylative N-alkylation of ?-amino acids employing ruthenium- and iron-based catalysts is presented. The reported method allows the synthesis of a wide range of five- and six-membered N-alkylated heterocycles in moderate-to-excellent yields starting from predominantly proline and a broad range of benzyl alcohols, and primary and secondary aliphatic alcohols. Examples using pipecolic acid for the construction of piperidine derivatives, as well as the one-pot synthesis of ?-amino nitriles, are also shown.

SUBMITTER: Afanasenko A 

PROVIDER: S-EPMC6772061 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature