Ontology highlight
ABSTRACT:
SUBMITTER: Afanasenko A
PROVIDER: S-EPMC6772061 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
ChemSusChem 20190722 16
A modular and waste-free strategy for constructing N-substituted cyclic amines via decarboxylative N-alkylation of α-amino acids employing ruthenium- and iron-based catalysts is presented. The reported method allows the synthesis of a wide range of five- and six-membered N-alkylated heterocycles in moderate-to-excellent yields starting from predominantly proline and a broad range of benzyl alcohols, and primary and secondary aliphatic alcohols. Examples using pipecolic acid for the construction ...[more]