Soluble HLA-G levels in seminal plasma are associated with HLA-G 3'UTR genotypes and haplotypes.
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ABSTRACT:
SUBMITTER: Craenmehr MHC
PROVIDER: S-EPMC6772099 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Soluble HLA-G levels in seminal plasma are associated with HLA-G 3'UTR genotypes and haplotypes.
Craenmehr Moniek H C MHC Haasnoot Geert W GW Drabbels Jos J M JJM Spruyt-Gerritse Marijke J MJ Cao Milo M van der Keur Carin C Kapsenberg Johanna M JM Uyar-Mercankaya Merve M van Beelen Els E Meuleman Tess T van der Hoorn Marie-Louise P MP Heidt Sebastiaan S Claas Frans H J FHJ Eikmans Michael M
HLA 20190808 4
Soluble HLA-G (sHLA-G) levels in human seminal plasma (SP) can be diverse and may affect the establishment of maternal-fetal tolerance and thereby the outcome of pregnancy. We investigated whether sHLA-G levels in SP are associated with polymorphisms in the 3'-untranslated region (UTR) and UTR haplotypes of the HLA-G gene. Furthermore, we compared the HLA-G genotype distribution and sHLA-G levels between men, whose partner experienced unexplained recurrent miscarriage (RM), and controls. Soluble ...[more]
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