Phase shifting the retinal circadian clock: xPer2 mRNA induction by light and dopamine.
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ABSTRACT:
SUBMITTER: Steenhard BM
PROVIDER: S-EPMC6773079 | biostudies-literature | 2000 Dec
REPOSITORIES: biostudies-literature
Publications
Phase shifting the retinal circadian clock: xPer2 mRNA induction by light and dopamine.
Steenhard B M BM Besharse J C JC
The Journal of neuroscience : the official journal of the Society for Neuroscience 20001201 23
A circadian clock is located in the retinal photoreceptors of the African clawed frog Xenopus laevis. These photoreceptor clocks are thought to govern a wide variety of output rhythms, including melatonin release and gene expression. Both light and dopamine phase shift the retinal clock in a phase-dependent manner. Two homologs of the Drosophila period gene have been cloned in Xenopus, and one of these (xPer2) is acutely regulated by light. Light and dopamine induce xPer2 mRNA in a similar manne ...[more]
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