Myotubularin related protein 7 is essential for the spermatogonial stem cell homeostasis via PI3K/AKT signaling.
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ABSTRACT:
SUBMITTER: Zhao D
PROVIDER: S-EPMC6773228 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
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Myotubularin related protein 7 is essential for the spermatogonial stem cell homeostasis via PI3K/AKT signaling.
Zhao Dan D Shen Cong C Gao Tingting T Li Hong H Guo Yueshuai Y Li Feng F Liu Chenchen C Liu Yuanyuan Y Chen Xia X Zhang Xi X Wu Yangyang Y Yu Yi Y Lin Meng M Yuan Yan Y Chen Xiaofang X Huang Xiaoyan X Yang Shenmin S Yu Jun J Zhang Jun J Zheng Bo B
Cell cycle (Georgetown, Tex.) 20190903 20
Myotubularin related protein 7 (MTMR7), a key member of the MTMR family, depicts phosphatase activity and is involved in myogenesis and tumor growth. We have previously identified MTMR7 in the proteomic profile of mouse spermatogonial stem cell (SSC) maturation and differentiation, implying that MTMR7 is associated with neonatal testicular development. In this study, to further explore the distribution and function of MTMR7 in mouse testis, we studied the effect of <i>Mtmr7</i> knockdown on neon ...[more]
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