Unknown

Dataset Information

0

Heterologous protection against Crimean-Congo hemorrhagic fever in mice after a single dose of replicon particle vaccine.

ABSTRACT: No vaccines are currently licensed to prevent Crimean-Congo hemorrhagic fever virus (CCHFV) infection, which can cause mild self-limiting clinical signs or severe, often fatal hemorrhagic fever disease. Here we continued investigations into the utility of a single-dose virus replicon particle (VRP) vaccine regimen by assessing protection against Turkey or Oman strains of CCHFV. We found that all mice were completely protected from disease, supporting broad applicability of this platform for CCHFV prevention.

SUBMITTER: Spengler JR 

PROVIDER: S-EPMC6773275 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Heterologous protection against Crimean-Congo hemorrhagic fever in mice after a single dose of replicon particle vaccine.

Spengler Jessica R JR   Welch Stephen R SR   Scholte Florine E M FEM   Coleman-McCray JoAnn D JD   Harmon Jessica R JR   Nichol Stuart T ST   Bergeron Éric É   Spiropoulou Christina F CF  

Antiviral research 20190801

No vaccines are currently licensed to prevent Crimean-Congo hemorrhagic fever virus (CCHFV) infection, which can cause mild self-limiting clinical signs or severe, often fatal hemorrhagic fever disease. Here we continued investigations into the utility of a single-dose virus replicon particle (VRP) vaccine regimen by assessing protection against Turkey or Oman strains of CCHFV. We found that all mice were completely protected from disease, supporting broad applicability of this platform for CCHF  ...[more]

Similar Datasets

Unknown Immunogenicity of a DNA-Based Sindbis Replicon Expressing Crimean-Congo Hemorrhagic Fever Virus Nucleoprotein.
| S-EPMC8703447 | biostudies-literature
Unknown Nucleocapsid protein-based vaccine provides protection in mice against lethal Crimean-Congo hemorrhagic fever virus challenge.
| S-EPMC6062107 | biostudies-literature
Unknown Crimean-Congo hemorrhagic fever in Bulgaria.
| S-EPMC3320408 | biostudies-literature
Unknown Crimean-Congo hemorrhagic fever in Turkey.
| S-EPMC3320426 | biostudies-literature
Unknown Crimean-Congo hemorrhagic fever, southwestern Bulgaria.
| S-EPMC2727343 | biostudies-literature
Unknown Crimean-Congo hemorrhagic fever in Kosovo.
| S-EPMC120293 | biostudies-literature
Unknown Crimean-Congo hemorrhagic fever in Iran.
| S-EPMC4260932 | biostudies-literature
Unknown Accelerated DNA vaccine regimen provides protection against Crimean-Congo hemorrhagic fever virus challenge in a macaque model.
| S-EPMC9931546 | biostudies-literature
Unknown Phylogeography of Crimean Congo Hemorrhagic Fever Virus.
| S-EPMC5120814 | biostudies-literature
Unknown Diagnostic assays for Crimean-Congo hemorrhagic fever.
| S-EPMC3557897 | biostudies-literature