The Autophagy Lysosomal Pathway and Neurodegeneration.
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ABSTRACT:
SUBMITTER: Finkbeiner S
PROVIDER: S-EPMC6773515 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
The Autophagy Lysosomal Pathway and Neurodegeneration.
Cold Spring Harbor perspectives in biology 20200302 3
The autophagy lysosomal pathway (ALP) is a major mechanism for degrading intracellular macromolecules. The catabolic products can then be used by the cell for energy or as building blocks to make other macromolecules. Since its discovery, a variety of cellular pathways have emerged that target components with varying specificity for lysosomal degradation. Under some circumstances, lysosomes may release their contents into the extracellular space where they may serve signaling or pathogenic funct ...[more]
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