Ontology highlight
ABSTRACT:
SUBMITTER: Masso-Valles D
PROVIDER: S-EPMC6773609 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Massó-Vallés Daniel D Massó-Vallés Daniel D Jauset Toni T Serrano Erika E Sodir Nicole M NM Pedersen Kim K Affara Nesrine I NI Whitfield Jonathan R JR Beaulieu Marie-Eve ME Evan Gerard I GI Elias Laurence L Arribas Joaquín J Soucek Laura L
Cancer research 20150401 8
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense stromal fibroinflammatory reaction that is a major obstacle to effective therapy. The desmoplastic stroma comprises many inflammatory cells, in particular mast cells as key components of the PDAC microenvironment, and such infiltration correlates with poor patient outcome. Indeed, it has been hypothesized that stromal ablation is critical to improve clinical response in patients with PDAC. Ibrutinib is a clinically approved Brut ...[more]