Ontology highlight
ABSTRACT:
SUBMITTER: Rosendale M
PROVIDER: S-EPMC6773865 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Nature communications 20191001 1
During clathrin mediated endocytosis (CME), the concerted action of dynamin and its interacting partners drives membrane scission. Essential interactions occur between the proline/arginine-rich domain of dynamin (dynPRD) and the Src-homology domain 3 (SH3) of various proteins including amphiphysins. Here we show that multiple SH3 domains must bind simultaneously to dynPRD through three adjacent motifs for dynamin's efficient recruitment and function. First, we show that mutant dynamins modified ...[more]