Ontology highlight
ABSTRACT:
SUBMITTER: Hur EM
PROVIDER: S-EPMC6774422 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
BMB reports 20190901 9
Recent evidence from genetics, animal model systems and biochemical studies suggests that defects in membrane trafficking play an important part in the pathophysiology of Parkinson's disease (PD). Mutations in leucine-rich repeat kinase 2 (LRRK2) constitute the most frequent genetic cause of both familial and sporadic PD, and LRRK2 has been suggested as a druggable target for PD. Although the precise physiological function of LRRK2 remains largely unknown, mounting evidence suggests that LRRK2 c ...[more]