Unknown

Dataset Information

0

Label-free sensitive detection of influenza virus using PZT discs with a synthetic sialylglycopolymer receptor layer.


ABSTRACT: We describe rapid, label-free detection of Influenza A viruses using the first radial mode of oscillations of lead zirconate titanate (PZT) piezoelectric discs with a 2 mm radius and 100 µm thickness fabricated from a piezoelectric membrane. The discs are modified with a synthetic sialylglycopolymer receptor layer, and the coated discs are inserted in a flowing virus suspension. Label-free detection of the virus is achieved by monitoring the disc radial mode resonance frequency shift. Piezo transducers with sialylglycopolymer sensor layers exhibited a long lifetime, a high sensitivity and the possibility of regeneration. We demonstrate positive, label-free detection of Influenza A viruses at concentrations below 105 virus particles per millilitre. We show that label-free, selective, sensitive detection of influenza viruses by home appliances is possible in principle.

SUBMITTER: Erofeev AS 

PROVIDER: S-EPMC6774986 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Label-free sensitive detection of influenza virus using PZT discs with a synthetic sialylglycopolymer receptor layer.

Erofeev Alexander S AS   Gorelkin Petr V PV   Kolesov Dmitry V DV   Kiselev Gleb A GA   Dubrovin Evgeniy V EV   Yaminsky Igor V IV  

Royal Society open science 20190918 9


We describe rapid, label-free detection of Influenza A viruses using the first radial mode of oscillations of lead zirconate titanate (PZT) piezoelectric discs with a 2 mm radius and 100 µm thickness fabricated from a piezoelectric membrane. The discs are modified with a synthetic sialylglycopolymer receptor layer, and the coated discs are inserted in a flowing virus suspension. Label-free detection of the virus is achieved by monitoring the disc radial mode resonance frequency shift. Piezo tran  ...[more]

Similar Datasets

| S-EPMC7087674 | biostudies-literature
| S-EPMC7127512 | biostudies-literature
| S-EPMC4392172 | biostudies-literature
| S-EPMC3729447 | biostudies-literature
| S-EPMC3065545 | biostudies-literature
| S-EPMC10496891 | biostudies-literature
| S-EPMC6483365 | biostudies-literature
| S-EPMC4541844 | biostudies-literature
| S-EPMC2944469 | biostudies-literature
| S-EPMC2077262 | biostudies-literature