Ontology highlight
ABSTRACT:
SUBMITTER: Tezil T
PROVIDER: S-EPMC6775102 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Tezil Tugsan T Chamoli Manish M Ng Che-Ping CP Simon Roman P RP Butler Victoria J VJ Jung Manfred M Andersen Julie J Kao Aimee W AW Verdin Eric E
NPJ aging and mechanisms of disease 20191002
Aging is characterized by the progressive loss of physiological function in all organisms. Remarkably, the aging process can be modulated by environmental modifications, including diet and small molecules. The natural compound nordihydroguaiaretic acid (NDGA) robustly increases lifespan in flies and mice, but its mechanism of action remains unclear. Here, we report that NDGA is an inhibitor of the epigenetic regulator p300. We find that NDGA inhibits p300 acetyltransferase activity in vitro and ...[more]