Ontology highlight
ABSTRACT:
SUBMITTER: Olechnowicz SWZ
PROVIDER: S-EPMC6775275 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Scientific reports 20191002 1
Interactions between multiple myeloma (MM) and bone marrow (BM) are well documented to support tumour growth, yet the cellular mechanisms underlying pain in MM are poorly understood. We have used in vivo murine models of MM to show significant induction of nerve growth factor (NGF) by the tumour-bearing bone microenvironment, alongside other known pain-related characteristics such as spinal glial cell activation and reduced locomotion. NGF was not expressed by MM cells, yet bone stromal cells su ...[more]