Ontology highlight
ABSTRACT:
SUBMITTER: Deng Y
PROVIDER: S-EPMC6775314 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Deng Yunfei Y Wang Jun J Xie Guojin G Zeng Xiaochen X Li Hongli H
International journal of biological sciences 20190907 11
Overactivation of β-adrenergic receptor (β-AR) can improve cardiac function temporarily but promotes the development and mortality of heart failure (HF) in the long run. CircRNA, a member of noncoding RNAs, can tolerate digestion of exonuclease and be a chronic stimulator to cell. But the relationship of circRNA with HF remains a puzzle and needs to be explored. Here, we found that circ-HIPK3 affected the concentration of Ca<sup>2+</sup> in cytoplasm by miR-17-3p through ADCY6 (Adenylate cyclase ...[more]