Different routes of insulin administration do not influence serum free thiols in type 1 diabetes mellitus.

ABSTRACT:

Aims

Intraperitoneal (IP) insulin administration is a last-resort treatment option for selected patients with type 1 diabetes mellitus (T1DM). As the IP route of insulin administration mimics the physiology more closely than the subcutaneous (SC) route, we hypothesized that IP insulin would result in less oxidative stress (expressed as systemic level of free sulphydryl (R-SH) content) compared to SC insulin in subjects with T1DM.

Materials and methods

Prospective, observational case-control study. Serum thiol measurements were performed at baseline and at 26 weeks in age- and gender-matched patients with T1DM. Serum-free thiols, compounds with a R-SH group that are readily oxidized by reactive oxygen species, are considered to be a marker of systemic redox status.

Results

SUBMITTER: van Dijk PR 

PROVIDER: S-EPMC6775445 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature