Ontology highlight
ABSTRACT:
SUBMITTER: Bi Y
PROVIDER: S-EPMC6775682 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Bi Yanghui Y Kong Pengzhou P Zhang Ling L Cui Heyang H Xu Xiaoqin X Chang Feiyun F Yan Ting T Li Jiayi J Cheng Caixia C Song Bin B Niu Xia X Liu Xiangchen X Liu Xue X Xu Enwei E Hu Xiaoling X Qian Yu Y Wang Fang F Li Hongyi H Ma Yanchun Y Yang Jian J Liu Yiqian Y Zhai Yuanfang Y Wang Yi Y Zhang Yingchun Y Liu Haiyan H Liu Jing J Wang Jintao J Cui Yongping Y Cheng Xiaolong X
Journal of Cancer 20190829 22
E1A Binding Protein P300 (EP300) is one of the mutations of genes involved in histone modifications in esophageal squamous cell carcinoma (ESCC). However, its clinical relevance, potential function and mechanisms have remained elusive. <b>Methods</b>: Genomic sequencing datas from 325 esophageal squamous cell carcinoma (ESCC) cases were integrated and screened a series of frequently mutated histone modifier genes. EP300 was selected to further analyze its clinical significance, function and RNA- ...[more]