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Challenges to Quantify Total Vitamin Activity: How to Combine the Contribution of Diverse Vitamers?

ABSTRACT: This state-of-the-art review aims to highlight the challenges in quantifying vitamin activity in foods that contain several vitamers of a group, using as examples the fat-soluble vitamins A and D as well as the water-soluble folate. The absorption, metabolism, and physiology of these examples are described along with the current analytical methodology, with an emphasis on approaches to standardization. Moreover, the major food sources for the vitamins are numerated. The article focuses particularly on outlining the so-called SLAMENGHI factors influencing a vitamer's' ability to act as a vitamin, that is, molecular species, linkage, amount, matrix, effectors of absorption, nutrition status, genetics, host-related factors, and the interaction of these. After summarizing the current approaches to estimating the total content of each vitamin group, the review concludes by outlining the research gaps and future perspectives in vitamin analysis. There are no standardized methods for the quantification of the vitamers of vitamin A, vitamin D, and folate in foods. For folate and ?-carotene, a difference in vitamer activity between foods and supplements has been confirmed, whereas no difference has been observed for vitamin D. For differences in vitamer activity between provitamin A carotenoids and retinol, and between 25-hydroxyvitamin D and vitamin D, international consensus is lacking. The challenges facing each of the specific vitamin communities are the gaps in knowledge about bioaccessibility and bioavailability for each of the various vitamers. The differences between the vitamins make it difficult to formulate a common strategy for assessing the quantitative differences between the vitamers. In the future, optimized stationary digestive models and the more advanced dynamic digestive models combined with in vitro models for bioavailability could more closely resemble in vivo results. New knowledge will enable us to transfer nutrient recommendations into improved dietary advice to increase public health throughout the human life cycle.

SUBMITTER: Jakobsen J

PROVIDER: S-EPMC6776468 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Challenges to Quantify Total Vitamin Activity: How to Combine the Contribution of Diverse Vitamers?

Jakobsen Jette J Melse-Boonstra Alida A Rychlik Michael M

Current developments in nutrition 20190725 10

This state-of-the-art review aims to highlight the challenges in quantifying vitamin activity in foods that contain several vitamers of a group, using as examples the fat-soluble vitamins A and D as well as the water-soluble folate. The absorption, metabolism, and physiology of these examples are described along with the current analytical methodology, with an emphasis on approaches to standardization. Moreover, the major food sources for the vitamins are numerated. The article focuses particula ...[more]

PMID: 31598575

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Project description:Accelerometers are widely used to measure physical activity behaviour, including in children. The traditional method for processing acceleration data uses cut points to define physical activity intensity, relying on calibration studies that relate the magnitude of acceleration to energy expenditure. However, these relationships do not generalise across diverse populations and hence they must be parametrised for each subpopulation (e.g., age groups) which is costly and makes studies across diverse populations and over time difficult. A data-driven approach that allows physical activity intensity states to emerge from the data, without relying on parameters derived from external populations, offers a new perspective on this problem and potentially improved results. We applied an unsupervised machine learning approach, namely a hidden semi-Markov model, to segment and cluster the raw accelerometer data recorded (using a waist-worn ActiGraph GT3X+) from 279 children (9-38 months old) with a diverse range of developmental abilities (measured using the Paediatric Evaluation of Disability Inventory-Computer Adaptive Testing measure). We benchmarked this analysis with the cut points approach, calculated using thresholds from the literature which had been validated using the same device and for a population which most closely matched ours. Time spent active as measured by this unsupervised approach correlated more strongly with PEDI-CAT measures of the child's mobility (R2: 0.51 vs 0.39), social-cognitive capacity (R2: 0.32 vs 0.20), responsibility (R2: 0.21 vs 0.13), daily activity (R2: 0.35 vs 0.24), and age (R2: 0.15 vs 0.1) than that measured using the cut points approach. Unsupervised machine learning offers the potential to provide a more sensitive, appropriate, and cost-effective approach to quantifying physical activity behaviour in diverse populations, compared to the current cut points approach. This, in turn, supports research that is more inclusive of diverse or rapidly changing populations.

Project description:BackgroundThe demand for naturally derived products is continuously growing. Nutraceuticals such as pre- and post-biotics, antioxidants and vitamins are prominent examples in this scenario, but many of them are mainly produced by chemical synthesis. The global folate market is expected to register a CAGR of 5.3% from 2019 to 2024 and reach USD 1.02 billion by the end of 2024. Vitamin B9, commonly known as folate, is an essential micronutrient for humans. Acting as a cofactor in one-carbon transfer reactions, it is involved in many biochemical pathways, among which the synthesis of nucleotides and amino acids. In addition to plants, many microorganisms can naturally produce it, and this can pave the way for establishing production processes. In this work, we explored the use of Scheffersomyces stipitis for the production of natural vitamin B9 by microbial fermentation as a sustainable alternative to chemical synthesis.ResultsGlucose and xylose are the main sugars released during the pretreatment and hydrolysis processes of several residual lignocellulosic biomasses (such as corn stover, wheat straw or bagasse). We optimized the growth conditions in minimal medium formulated with these sugars and investigated the key role of oxygenation and nitrogen source on folate production. Vitamin B9 production was first assessed in shake flasks and then in bioreactor, obtaining a folate production up to 3.7 ± 0.07 mg/L, which to date is the highest found in literature when considering wild type microorganisms. Moreover, the production of folate was almost entirely shifted toward reduced vitamers, which are those metabolically active for humans.ConclusionsFor the first time, the non-Saccharomyces yeast S. stipitis was used to produce folate. The results confirm its potential as a microbial cell factory for folate production, which can be also improved both by genetic engineering strategies and by fine-tuning the fermentation conditions and nutrient requirements.

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Challenges to Quantify Total Vitamin Activity: How to Combine the Contribution of Diverse Vitamers?

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Challenges to Quantify Total Vitamin Activity: How to Combine the Contribution of Diverse Vitamers?

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