Genetic risk for Alzheimer's dementia predicts motor deficits through multi-omic systems in older adults.

ABSTRACT: Alzheimer's disease manifests with both cognitive and motor deficits. However, the degree to which genetic risk of Alzheimer's dementia contributes to late-life motor impairment, and the specific molecular systems underlying these associations, are uncertain. Here, we adopted an integrative multi-omic approach to assess genetic influence on motor impairment in older adults and identified key molecular pathways that may mediate this risk. We built a polygenic risk score for clinical diagnosis of Alzheimer's dementia (AD-PRS) and examined its relationship to several motor phenotypes in 1885 older individuals from two longitudinal aging cohorts. We found that AD-PRS was associated with a previously validated composite motor scores and their components. The major genetic risk factor for sporad

SUBMITTER: Tasaki S 

PROVIDER: S-EPMC6776503 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature