Gingival solitary chemosensory cells are immune sentinels for periodontitis.
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ABSTRACT:
SUBMITTER: Zheng X
PROVIDER: S-EPMC6776549 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Gingival solitary chemosensory cells are immune sentinels for periodontitis.
Zheng Xin X Tizzano Marco M Redding Kevin K He Jinzhi J Peng Xian X Jiang Peihua P Xu Xin X Zhou Xuedong X Margolskee Robert F RF
Nature communications 20191003 1
Solitary chemosensory cells (SCCs) are epithelial sentinels that utilize bitter Tas2r receptors and coupled taste transduction elements to detect pathogenic bacterial metabolites, triggering host defenses to control the infection. Here we report that SCCs are present in mouse gingival junctional epithelium, where they express several Tas2rs and the taste signaling components α-gustducin (Gnat3), TrpM5, and Plcβ2. Gnat3<sup>-/-</sup> mice have altered commensal oral microbiota and accelerated nat ...[more]
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