Ontology highlight
ABSTRACT:
SUBMITTER: Kim GB
PROVIDER: S-EPMC6776630 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Kim Gloria B GB Hege Kristen K Riley James L JL
Frontiers in immunology 20190927
Re-directing T cells via chimeric antigen receptors (CARs) was first tested in HIV-infected individuals with limited success, but these pioneering studies laid the groundwork for the clinically successful CD19 CARs that were recently FDA approved. Now there is great interest in revisiting the concept of using CAR-expressing T cells as part of a strategy to cure HIV. Many lessons have been learned on how to best engineer T cells to cure cancer, but not all of these lessons apply when developing C ...[more]