Ontology highlight
ABSTRACT:
SUBMITTER: Jahng JWS
PROVIDER: S-EPMC6776927 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Jahng James Won Suk JWS Alsaadi Reham Musaibeh RM Palanivel Rengasamy R Song Erfei E Hipolito Victoria Emily Barbosa VEB Sung Hye Kyoung HK Botelho Roberto Jorge RJ Russell Ryan Charles RC Sweeney Gary G
EMBO reports 20190823 10
Iron overload, a common clinical occurrence, is implicated in the metabolic syndrome although the contributing pathophysiological mechanisms are not fully defined. We show that prolonged iron overload results in an autophagy defect associated with accumulation of dysfunctional autolysosomes and loss of free lysosomes in skeletal muscle. These autophagy defects contribute to impaired insulin-stimulated glucose uptake and insulin signaling. Mechanistically, we show that iron overload leads to a de ...[more]