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Changes in serum markers of patients with PCOS during consecutive clomiphene stimulation cycles: a retrospective study.


ABSTRACT:

Background

A retrospective case-control study was performed to evaluate whether PCOS-specific serum markers would change in women with polycystic ovary syndrome (PCOS) during the course of two consecutive cycles of clomiphene citrate (CC)-stimulation, which did not lead to a pregnancy.

Methods

Anovulatory PCOS patients who underwent two consecutive CC-cycles (n?=?41) and anovulatory PCOS controls who chose an observational approach for two months (n?=?24) were included in the study. The main outcome measures were levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), anti-Mullerian hormone (AMH), total testosterone, androstenedione, and sexual hormone binding globulin (SHBG).

Results

In the control group, PCOS-specific serum parameters did not change during two months (p?>?0.05). In the CC-group, there were decreases in LH (11.8?±?4.9?mU/mL vs. 10.9?±?4.0?mU/mL; p?=?0.029), the LH:FSH ratio (2.1?±?0.8?mU/mL vs. 1.8?±?0.5?mU/mL; p?=?0.007), and AMH (8.08?±?4.27?ng/mL vs. 7.17?±?3.37?ng/mL; p?=?0.011), as well as an increase in SHBG (46.0?±?20.2?nmol/L vs. 51.2?±?21.0?nmol/L; p?ConclusionTwo cycles of CC-stimulation that did not lead to a pregnancy were accompanied by mean LH, AMH, and LH:FSH ratio declines and an SHBG increase. The clinical significance seems of minor relevance.

SUBMITTER: Hager M 

PROVIDER: S-EPMC6777034 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Changes in serum markers of patients with PCOS during consecutive clomiphene stimulation cycles: a retrospective study.

Hager Marlene M   Hörath Steffen S   Frigo Peter P   Koch Marianne M   Marculescu Rodrig R   Ott Johannes J  

Journal of ovarian research 20191004 1


<h4>Background</h4>A retrospective case-control study was performed to evaluate whether PCOS-specific serum markers would change in women with polycystic ovary syndrome (PCOS) during the course of two consecutive cycles of clomiphene citrate (CC)-stimulation, which did not lead to a pregnancy.<h4>Methods</h4>Anovulatory PCOS patients who underwent two consecutive CC-cycles (n = 41) and anovulatory PCOS controls who chose an observational approach for two months (n = 24) were included in the stud  ...[more]

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