Dataset Information

A Case for Promoting Movement Medicine: Preventing Disability in the LIFE Randomized Controlled Trial.

ABSTRACT:

Background

The movement profile of older adults with compromised function is unknown, as is the relationship between these profiles and the development of major mobility disability (MMD)-a critical clinical outcome. We first describe the dimensions of movement in older adults with compromised function and then examine whether these dimensions predict the onset of MMD.

Methods

Older adults at risk for MMD (N = 1,022, mean age = 78.7 years) were randomized to receive a structured physical activity intervention or health education control. We assessed MMD in 6-month intervals (average follow-up of 2.2 years until incident MMD), with activity assessed at baseline, 6-, 12- and 24-month follow-up via accelerometry.

Results

A principal components analysis of 11 accelerometer-derived metrics yielded three components representing lifestyle movement (LM), extended bouts of moderate-to-vigorous physical activity (MVPA), and stationary body posture. LM accounted for the greatest proportion of variance in movement (53%). Within health education, both baseline LM (HR = 0.74; 95% CI 0.62 to 0.88) and moderate-to-vigorous physical activity (HR = 0.69; 95% CI 0.54 to 0.87) were associated with MMD, whereas only LM was associated with MMD within physical activity (HR = 0.74; 95% CI 0.61 to 0.89). There were similar nonlinear relationships present for LM in both physical activity and health education (p < .04), whereby risk for MMD was lower among individuals with higher levels of LM.

Conclusions

Both LM and moderate-to-vigorous physical activity should be central in treatment regimens for older adults at risk for MMD.

Trial registration

clinicaltrials.gov Identifier NCT01072500.

SUBMITTER: Fanning J

PROVIDER: S-EPMC6777081 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Publications

A Case for Promoting Movement Medicine: Preventing Disability in the LIFE Randomized Controlled Trial.

Fanning Jason J Rejeski W Jack WJ Chen Shyh-Huei SH Nicklas Barbara J BJ Walkup Michael P MP Axtell Robert S RS Fielding Roger A RA Glynn Nancy W NW King Abby C AC Manini Todd M TM McDermott Mary M MM Newman Anne B AB Pahor Marco M Tudor-Locke Catrine C Miller Michael E ME

The journals of gerontology. Series A, Biological sciences and medical sciences 20191001 11

<h4>Background</h4>The movement profile of older adults with compromised function is unknown, as is the relationship between these profiles and the development of major mobility disability (MMD)-a critical clinical outcome. We first describe the dimensions of movement in older adults with compromised function and then examine whether these dimensions predict the onset of MMD.<h4>Methods</h4>Older adults at risk for MMD (N = 1,022, mean age = 78.7 years) were randomized to receive a structured ph ...[more]

PMID: 30778518

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Dataset Information

A Case for Promoting Movement Medicine: Preventing Disability in the LIFE Randomized Controlled Trial.

Background

Methods

Results

Conclusions

Trial registration

Publications

A Case for Promoting Movement Medicine: Preventing Disability in the LIFE Randomized Controlled Trial.

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